公司名稱：南京康佰生物科技有限公司
地址:南京市雨花區長虹路222號
郵編：
電話：025-86880024
手機: 18066071954
聯系人: 蔣
傳真：
E-mail: duhaitao@cobioer.com
地址:南京市雨花區長虹路222號
郵編：
電話：025-86880024
手機: 18066071954
聯系人: 蔣
傳真：
E-mail: duhaitao@cobioer.com
CBP73334PDGFRA D842V-G680R/BaF3 Kinase細胞株的詳細資料：
| CBP73334 | |
| I. Introduction | |
Cell Line Name： | PDGFRA D842V-G680R/BaF3 |
Gene Synonyms: | PDGFRA |
Host Cell: | Ba/F3 |
| Stability: | 16 passages |
Application: | |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | 1640+10%FBS+2ug/ml puromycin |
Mycoplasma Status: | Negative |
| II.Background | |
PDGFRA D842V lies within the protein kinase domain of the Pdgfra protein (UniProt.org). D842V results in ligand-independent phosphorylation of Pdgfra, activation of downstream signaling, and is transforming in culture (PMID: 22745105, PMID: 23752188, PMID: 29533785, PMID: 30253204) and confers resistance to PDGFRA inhibitors (PMID: 30389923, PMID: 18955458). | |
| III. Representative Data | |
1.Sanger of PDGFRA D842V-G680R/BaF3
Figure 1. PDGFRA D842V-G680R/BaF3 G680R
Figure 2. PDGFRA D842V-G680R/BaF3 D842V | |
2. Anti-proliferation assay | |
Figure 3. CTG Proliferation Assay of BaF3 PDGFRA D842V/G680R Cells (C1). | |
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