地址:南京市雨花區長虹路222號
郵編：
電話：025-86880024
手機: 18066071954
聯系人: 蔣
傳真：
E-mail: duhaitao@cobioer.com
CBP73321BCR-ABL1 G250E/BaF3的詳細資料：
| CBP73321 | |
| I. Introduction | |
Cell Line Name： | BCR-ABL1 [G250E]/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | |
Mycoplasma Status: | Negative |
| II.Background | |
Presence of a BCR-ABL1 fusion gene is necessary for the pathogenesis of CML. In up to 95% of cases, a t(9;22) (q34;q11) translocation results in the BCR-ABL1 fusion gene (Faderl et al. 1999). This translocation results in the Philadephia chromosome. In rare CML cases lacking the traditional t(9;22) translocation, other translocations result in the creation of the BCR-ABL1 fusion gene, which sometimes involve multiple chromosomes. ABL1 is a tyrosine kinase, and, in normal cells, it plays a role in cellular differentiation and regulation of the cell cycle. The BCR-ABL1 fusion gene creates a constitutively active tyrosine kinase, which leads to uncontrolled proliferation. | |
| III. Representative Data | |
1.Sanger of BCR-ABL1 [G250E]/BaF3
Figure 1. BCR-ABL1 [G250E]/BaF3 G250E
Figure 2. BCR-ABL1 [G250E]/BaF3 Fusion | |
2. Anti-proliferation assay
Figure 2. CTG Proliferation Assay of BaF3 BCR-ABL1 G250E Cells (C3). | |
