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CBP73181EGFR S768_V769delinsIL（S768I/V769L）/BaF3的詳細資料：
EGFR S768_V769delinsIL(S768I/V769L)/BaF3
| CBP73181 | |
| I. Introduction | |
Cell Line Name： | EGFR S768_V769delinsIL(S768I&V769L)/BaF3 |
Gene Synonyms: | ERBB, mENA, ERBB1, HER1 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages |
Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | 1640+10%FBS+2ug/ml puromycin |
Mycoplasma Status: | Negative |
| II.Background | |
EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. EGFR S768_V769delinsIL results in a deletion of two amino acids in the protein kinase domain of the Egfr protein from aa 768 to aa 769, combined with the insertion of an isoleucine (I) and a leucine (L) at the same site (UniProt.org). S768_V769delinsIL has been identified in the scientific literature (PMID: 17045698, PMID: 27304188), but has not been biochemically characterized and therefore, its effect on Egfr protein function is unknown (PubMed, Jul 2019). | |
| III. Representative Data | |
1. Anti-proliferation assay | |
Figure . Anti-proliferation assay of three reference compounds on the EGFR S768_V769delinsIL(S768I&V769L)/BaF3 Stable Cell Line | |