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CBP73218EGFR D770_N771insY/BaF3激酶細胞的詳細資料：
EGFR D770_N771insY/BaF3激酶細胞
| CBP73218 | |
| I. Introduction | |
Cell Line Name： | EGFR D770_N771insY/BaF3 |
Gene Synonyms: | ERBB, mENA, ERBB1, HER1 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages |
Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | |
Mycoplasma Status: | Negative |
| II.Background | |
EGFR D770_N771insY results in the insertion of a tyrosine (Y) in the protein kinase domain of the Egfr protein between amino acids 770 and 771 (UniProt.org). D770_N771insY has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions (PMID: 24353160). | |
| III. Representative Data | |
1. Anti-proliferation assay | |
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Figure . Anti-proliferation assay of three reference compounds on the EGFR D770_N771insY/BaF3 Stable Cell Line | |